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Match List I with List II. List I: A. Down's syndrome; B. α-Thalassemia; C. β-Thalassemia; D. Klinefelter's syndrome. List II: I. 11th chromosome; II. 'X' chromosome; III. 21st chromosome; IV. 16th chromosome. Choose the correct answer from the options given below:
Down = Trisomy 21 (III); α-Thalassemia = Chromosome 16 (IV); β-Thalassemia = Chromosome 11 (I); Klinefelter = 47, XXY on sex chromosome X (II)! Match: A-III, B-IV, C-I, D-II!
Down’s syndrome is an aneuploid condition caused by the presence of an additional copy of chromosome number 21 (trisomy 21) (A -> III). Klinefelter’s syndrome is caused due to the presence of an additional copy of the X-chromosome resulting into a karyotype of 47, XXY (D -> II).
Thalassemia is an autosome-linked recessive blood disease. α-Thalassemia is controlled by two closely linked genes HBA1 and HBA2 on chromosome 16 of each parent (B -> IV). β-Thalassemia is controlled by a single gene HBB on chromosome 11 of each parent (C -> I).
The resulting mapping is A-III, B-IV, C-I, D-II, corresponding to Option (1).
Diagnose every choice: Know exactly why the right option works and why distractors fail.
Accurately pairs each genetic/chromosomal syndrome with its specific autosome or sex chromosome.
Mismatches Down’s syndrome with chromosome 16 and Klinefelter’s with chromosome 21.
Mismatches Down’s with chromosome 11.
Mismatches Down’s with the X chromosome.
Confusing chromosome 16 (alpha) with chromosome 11 (beta).
"Down’s syndrome is caused by trisomy 21. Klinefelter’s syndrome is caused by an additional X chromosome (47, XXY). α-Thalassemia is controlled by genes on chromosome 16 while β-Thalassemia is controlled by a single gene on chromosome 11."
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