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Chronic auto immune disorder affecting neuro muscular junction leading to fatigue, weakening and paralysis of skeletal muscle is called as:
The verbatim NCERT clinical definition: "Myasthenia gravis: Auto-immune disorder affecting neuromuscular junction leading to fatigue, weakening and paralysis of skeletal muscle." Muscular dystrophy is genetic, arthritis/gout affect joints. Match Option (3) instantly!
Myasthenia gravis is a classic autoimmune disease of the peripheral nervous and muscular systems: - Autoantibodies (IgG) target and destroy nicotinic acetylcholine receptors (nAChRs) situated on the sarcolemma of the post-synaptic neuromuscular junction (NMJ). - When acetylcholine is released from motor neurons, fewer receptors are available to generate end-plate potentials. - Over time, repetitive muscular contraction fails, precipitating severe fatigue, flaccid weakness, and eventual paralysis of skeletal muscles (frequently initiating with ptosis of eyelids and diplopia).
- Arthritis: Inflammation of one or more joints, causing pain and stiffness. - Muscular dystrophy: Progressive degeneration of skeletal muscle caused by an X-linked recessive genetic defect (dystrophin gene mutation), NOT an autoimmune disorder. - Gout: Inflammation of joints caused by accumulation and crystallization of uric acid salts.
Diagnose every choice: Know exactly why the right option works and why distractors fail.
Incorrect. Arthritis involves inflammation of joints, not an autoimmune block of neuromuscular junctions.
Incorrect. Muscular dystrophy is a genetic defect (often Duchenne muscular dystrophy), not an autoimmune disorder.
Correct. Verbatim matches NCERT definition: chronic autoimmune condition targeting the neuromuscular junction leading to skeletal muscle fatigue and paralysis.
Incorrect. Gout is a metabolic disorder resulting from hyperuricemia and urate crystals in joint spaces.
NTA loves contrasting Myasthenia Gravis and Muscular Dystrophy. Both lead to muscle wasting and weakness, but their fundamental causes are entirely different.
"Myasthenia gravis is an autoimmune disorder affecting neuromuscular junctions, causing skeletal muscle weakness and paralysis."
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