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Q.59 Zoology ⭐ 360° Option Elimination Active
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NEET 2020 Zoology Question 59 Solution

Topic: Digestion and Absorption · Official NTA Booklet Code E1
NEET 2020 Zoology Question 59: Enzymatic Activation Cascade: Enterokinase and Trypsinogen Activation

Question

The enzyme enterokinase helps in conversion of:

  1. (1)protein into polypeptides
  2. (2)trypsinogen into trypsin
  3. (3)caseinogen into casein
  4. (4)pepsinogen into pepsin
✓
Verified Against NTA Final Answer Key
Option (2) : trypsinogen into trypsin
📚 Digestion and Absorption Easy
📋 Given Parameters & Problem Setup
Enzyme Enterokinase (enteropeptidase)
Site of Secretion Intestinal mucosa (succus entericus)
Question Objective Identify which biochemical conversion is catalyzed by enterokinase
⚡

The 30-Second Exam Hall Shortcut: ⚡ "Enterokinase Activates Pancreatic Trypsinogen -> Trypsin!"

⏱️ 20 seconds

Enterokinase is secreted by the intestinal mucosa and specifically converts inactive pancreatic trypsinogen into active trypsin. Active trypsin then autocatalytically activates all other pancreatic zymogens (chymotrypsinogen, procarboxypeptidase). Mark Option (2) in 5 seconds!

1 Intestinal mucosa secretes enterokinase.
2 Trypsinogen (inactive) + Enterokinase -> Trypsin (active).
3 Trypsin then activates other pancreatic enzymes.
4 Select Option (2) trypsinogen into trypsin.
🛡️
Why You Can 100% Trust This Shortcut: NCERT Biology · Human Physiology: Digestion and Absorption (Digestion of Food)
📐

Step-by-Step Rigorous Workflow & Mathematical Proof

Step 1

Origin and Role of Enterokinase

Enterokinase (also called enteropeptidase) is a brush-border proteolytic enzyme secreted by the duodenal intestinal mucosa.

Step 2

Target Zymogen and Reaction

Pancreatic juice contains inactive zymogens: trypsinogen, chymotrypsinogen, procarboxypeptidases, amylases, lipases, and nucleases. Enterokinase specifically cleaves a hexapeptide from inactive trypsinogen to convert it into active trypsin.

Step 3

Downstream Enzyme Activation Cascade

Once activated, trypsin acts as the master activator that proteolytically cleaves and activates the other inactive enzymes in the pancreatic juice (chymotrypsinogen into chymotrypsin, procarboxypeptidase into carboxypeptidase).

Step 4

Evaluate Other Conversions

Pepsinogen is converted into pepsin by gastric HCl (not enterokinase); caseinogen to casein involves rennin/pepsin. Thus, enterokinase uniquely activates trypsinogen into trypsin.

⭐

360° Option Elimination Engine Key Feature

Diagnose every choice: Know exactly why the right option works and why distractors fail.

4-Option Deep Scan
1 A
✗ Incorrect
Verdict & Scientific Reason:

Incorrect; the breakdown of proteins into polypeptides is catalyzed by pepsin, trypsin, and chymotrypsin, not by enterokinase directly.

⚠️
Student Fallacy (Why candidates pick this trap): Confusing an activating enzyme with main digestive proteases.
2 B
✓ 100% Correct
Verdict & Scientific Reason:

Factually exact; enterokinase cleaves the N-terminal inhibitory peptide from trypsinogen to yield active trypsin.

💡
Why this is airtight: None; core biochemical cascade step in digestion.
3 C
✗ Incorrect
Verdict & Scientific Reason:

Incorrect; curdling of milk protein involves rennin (in infants) or pepsin and calcium ions, not enterokinase.

⚠️
Student Fallacy (Why candidates pick this trap): Confusing milk protein curdling with pancreatic activation.
4 D
✗ Incorrect
Verdict & Scientific Reason:

Incorrect; pepsinogen is activated into pepsin by hydrochloric acid (HCl) in gastric juice, not by enterokinase.

⚠️
Student Fallacy (Why candidates pick this trap): Confusing gastric activation (HCl) with intestinal activation (enterokinase).
⚠️

NTA Trap Alert: Gastric vs Pancreatic Activation Trigger

Gastric: Pepsinogen -> Pepsin (by HCl). Pancreatic: Trypsinogen -> Trypsin (by Intestinal Enterokinase).

🛡️ How to avoid the -1 mark: Entero = Intestine; Enterokinase = Intestinal enzyme activating pancreatic trypsinogen!
📖

Core NEET Syllabus Standard

Zoology · Digestion and Absorption Standard Benchmark
Core Scientific Principle Tested:

""

Syllabus Focus: Enzymatic Activation Cascade: Enterokinase and Trypsinogen Activation
✓ Core NEET UG Syllabus Anchor Syllabus & Academic Standards ↗

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